Scientific american, august 2008, surprises from celiac disease by alessio fasano. Researchers have discovered a process that may contribute to many autoimmune disorders including cd. Scientific american is the essential guide to the most aweinspiring advances in science and technology. He is the head of research at the university of harvard celiac research center, and he is responsible for discovering the glutenleaky gut. Groundbreaking news about celiac in scientific american. Simple rules are better than complicated algorithms article pdf available in the american journal of medicine 1238. The worlds leading expert on glutenrelated disorders, dr.
Dr alessio fasano on celiac disease, gluten sensitivity. In a recent poll presented by scientific american, over 30% of americans. But for millions of americans affected by glutenrelated disorders, consuming gluten, the. Study of a potentially fatal foodtriggered disease has uncovered a process that may contribute to many. Fasano the acknowledged leader in the science of celiac. Multiple research studies have linked gluten to the condition known as intestinal permeability aka leaky gut syndrome. Scientific american 57 center for celiac research, university of maryland school of medicine micrographs. Tight junctions are a dark horse implicated in a host of disease states, ranging from acute injury to chronic inflammation and autoimmune diseases coomassie western blot. Fasano is also the author of numerous books and reports and articles. Gluten freedom by rich gannon foreword, alessio fasano 29 apr. Dr fasano, who published the groundbreaking study in the annals of medicine in 2003 that established the prevalence rate of celiac disease at one in 3 people in the us, was speaking to.
Formerly considered a pediatric disease, the rate of occurrence is now observed in individuals ranging from early childhood to senescence. The research group directed by alessio fasano is making enormous contributions to broadening medical understanding of celiac disease, expanding medical knowledge of autoimmunity and cancer, and increasing celiac awareness see. Topics include a brief overview of when humans started consuming seeds and seedbased foods such as fruit and wheat and how the switch from a nomadic life to an. I recently had the privilege of speaking with one of the leading gluten sensitivity researchers in the world, dr. Center for celiac research and treatment home facebook. Celiac disease cd is a tcell mediated genetically inherited autoimmune disease that has evolved over time. Some of his other books, in addition to gluten freedom include. The diagnosis of celiac disease involves serologic testing generally for iga antitissue transglutaminase antibodies first followed by upper endoscopy with biopsy for confirmation in most. The nations leading expert offers the essential guide to a healthy, glutenfree lifestyle. Clues to solving autoimmunity study of a potentially fatal foodtriggered disease has uncovered a process that may contribute. He serves as director of the center for celiac research and treatment at massgeneral hospital for children mghfc and co. Update 7222009 the forthcoming august 2009 issue of scientific american contains a fascinating indepth article about celiac disease. Groundbreaking news about celiac in scientific american july 22, 2009 a new study by dr. The part of the book that did focus more on the current state of the scientific.
Article by alessio fasano, a leading researcher on celiac disease, in scientific american. Gluten sensitivity and celiac disease center for human holistics. He currently holds many roles, including professor of pediatrics at harvard medical school and professor of nutrition at harvard t. The center for celiac research is recognized as a world leader in the field of celiac disease and gluten sensitivity and houses a. This can be due to intolerance or, more concerning, a diagnosis of celiac.
The nations leading expert offers the essential guide to a healthy, glutenfree lifestyle fasano, alessio, gannon, rich, flaherty, susie on. Gluten freedom and millions of other books are available for instant access. Center for celiac research and treatment, boston, ma. Scientific american magazine july 27, 2009 celiac disease insights. Alessio fasano is an italianborn medical doctor, pediatric gastroenterologist and researcher. The article discusses research investigating celiac disease cd, which is a foodtriggered disease that can be potentially fatal. Alessio fasano may reveal means of delaying or preventing celiac disease and offer help for other autoimmune disorders. Scientific american is the essential guide to the most aweinspiring advances in. Alessio fasano is a worldrenowned expert on celiac disease and other glutenrelated health disorders and his book, gluten freedom, is amazing.